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Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but They're uncommon With this malignancy as compared to other lymphoid neoplasms. CHD2 is mutated in 5% of CLL and 7% of MBL.seventy five The histone methyltransferase SETD2 and ARID1A are also mutated in a small proportion of clients. Of Take note, MYD88